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Cough syrup Kofex: instructions for use, contraindications

Cough syrup Kofex: instructions for use, contraindications

Kofex Cough Syrup is a combination preparation with antitussive and antihistamine (antiallergic) properties. The main active components of the drug – codeine phosphate and chlorpheniramine maleate – not only complement well, but also enhance the effectiveness of each other’s actions.

Release form: Kofeks is sold in dark bottles made of polymeric materials (each volume is 60 ml). In the cardboard box with the drug is also enclosed 1 measuring cap.

How syrup works

Chlorpheniramine maleate – an active substance with pronounced antiallergic properties, reduces the intensity of symptoms, the appearance of which is associated with the release of histamine. So, this component helps to eliminate the swelling, nasal congestion, reduces the permeability of the vascular walls, copes with heavy tearing, shows a mild sedative (hypnotic) effect.

Codeine phosphate acts on the cough center of the brain, thereby blocking seizures. Overdose is fraught with respiratory dysfunction.

The pharmacological properties of codeine are similar to morphine, but at the same time, the former exhibits less pronounced analgesic activity.

Within one and a half to two hours, the active components of Kofex syrup are absorbed in the gastrointestinal tract, about 90% of the accepted dose of codeine and chlorpheniramine is excreted (mainly by the kidneys) during the day.

When Kofex’s reception is indicated:

  • in respiratory diseases of various nature
  • for relief of unproductive cough
  • for the purpose of symptomatic treatment of allergic, infectious diseases.

How to take medicine

Instructions for cough syrup Kofex: the drug is intended for ingestion, drink it undiluted, you can drink the drug with a glass of boiled water. To reduce the risk of unpleasant symptoms on the part of the digestive tract, it is better to take the syrup immediately after eating.

For convenience of dispensing the bottle with syrup is equipped with a measured cap. Only the attending physician selects the amount and regimen of cough medicine.

In a generalized version of the scheme of use of the anti-cough syrup Kofex looks like

  • 5 ml / 4 times a day (adolescents, adult patients)
  • 2.5 ml / 4 times a day (children from 6 to 12 years).

Treatment is continued for 7–10 days.

Precautionary measures

Prolonged use of high doses of Kofex is fraught with a number of side effects. Thus, patients may experience irregular blood pressure, cardiac rhythm failure, tachycardia, an increase in blood platelet levels, leukopenia, agranulocytosis, aplastic anemia.

There is a risk of disturbances on the part of the nervous system – a problem with coordination of movements, headaches, asthenia, dizziness, confusion, irritability, anxiety, fainting, insomnia. During treatment, patients may increase intracranial pressure, there are convulsions, neurosis, vertigo.

The gastrointestinal tract can also respond to an overdose of Cofex cough syrup. Typical symptoms:

  • nausea
  • dyspeptic syndrome
  • discomfort, pain in the epigastric region
  • vomiting
  • anorexia
  • constipation or diarrhea.

Possible negative consequences of taking Kofex from the genitourinary system:

  • problems with urination (delay or, conversely, frequent urging)
  • failure of the menstrual cycle in women and erectile dysfunction in men
  • decrease in sexual desire.

Overdose of antitussive syrup can lead to various forms of allergic reactions – from urticaria to bronchospasm. Prolonged use of codeine is fraught with the appearance of withdrawal at the end of the treatment course.

This substance may be addictive.

Other possible symptoms against coughing with Kofex include hyperhidrosis, increased dryness of mucous membranes, rhinitis, blurred vision, dyskinesia, muscle spasms, flushing, hypothermia.

In case of drug overdose, patients are prescribed enterosorbents, they wash the stomach, give laxative drugs.

If symptoms of oppression of the central nervous system are present, symptomatic treatment is indicated to patients (in addition to stimulants).

Kofeks is stored for 2 years from the date of production in a room where the air temperature does not exceed the mark of +25 degrees. In no case can the syrup be frozen, otherwise the medicine will lose its medicinal properties.


It is better to refuse syrup intake to patients with individual intolerance to its components, as well as to patients who are already using other anti-allergic medicines and opioid analgesics.

Treatment Kofexom not carried out in such cases:

  • with obstructive respiratory diseases
  • pneumonia, emphysema, bronchial asthma
  • respiratory dysfunction
  • patients who have recently suffered a traumatic brain injury or suffer from increased intracranial pressure.

Do not prescribe Kofex for alcohol intoxication, chronic intestinal obstruction, hypertension, heart and kidney failure. Syrup is contraindicated in patients who have recently undergone surgery on the gallbladder or biliary tract.

It is better not to give Kofex cough syrup to children under 6 years of age; during treatment, adult patients are advised not to drive and control unsafe mechanisms (the drug has sedative properties).

Drug analogs (different composition, indications for use are identical):

As you can see, Kofex syrup is an effective antitussive drug with anti-allergic properties. The active components of the drug stop seizures, cope with unproductive cough, acting directly on the cough center of the brain.

In view of the presence of a large number of contraindications and a high risk of side effects from the nervous, cardiovascular, respiratory system and gastrointestinal organs, the treatment of cough with Cofex must necessarily be coordinated with the doctor.

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